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Ongoing Studies

1

Translational Neuroscience

We focus on translating discoveries in neuroscience into tangible solutions for aging-related psychiatric disorders. By bridging the gap between bench and bedside, we aim to develop innovative interventions, diagnostic tools, and therapeutic approaches to address conditions such as dementia and depression.

2

Disease Modifying Drugs for Alzheimer's Disease

By targeting the underlying mechanisms of neurodegeneration, these drugs aim to slow the progression of this devastating condition, offering potential relief for those affected and their loved ones.

3

Behavioral Symptoms of Alzheimer's Disease

Alzheimer's Disease often presents with a range of behavioral symptoms that can significantly impact both patients and their caregivers. We focus on identifying efficacious treatments for these common behavioral symptoms, including anxiety and agitation

CBD
CBD-AD Cannabidiol (CBD) for the Treatment of Anxiety and Agitation in MCI and Alzheimer's Dementia 
BACKGROUND

CBD-AD is an 8-week long trial assessing the effects of a high CBD/low THC solution in treating anxiety in older adults with mild cognitive impairment or Alzheimer’s Dementia. All subjects will receive the study product.

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Click here to learn more about the study  

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STUDY DETAILS

Looking for: 

  • Older adults ages 55-90 

  • With a diagnosis of mild cognitive impairment or Alzheimer’s dementia 

  • Who have a study partner to accompany you at all visits 

This study involves:

  • 8 weeks of participation including remote and in-person visits to McLean Hospital 

  • Urine and vital collection 

  • Provision of a sublingual solution at no personal cost 

  • Up to $300 compensation for study completion 

You or your loved one is/are not eligible if: 

  • Allergic to coconut 

  • Currently depressed 

  • Experiencing delirium 

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Click here to express interest 

NRAD
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NRAD: Brain Imaging Study of a Vitamin B3 Supplement 
BACKGROUND

NRAD is a 12-week long brain imaging study assessing the effects of a Vitamin B3 supplement, Nicotinamide Riboside (NR), on brain metabolism in older adults with mild cognitive impairment or Alzheimer’s dementia.  

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Click here to learn more about the study 

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STUDY DETAILS

Looking for:  

  • Older adults ages 55-89 

  • With a diagnosis of mild cognitive impairment or Alzheimer’s Dementia 

  • Have a study partner to accompany to all visits at McLean Hospital

This study involves: 

  • 3 visits over 12 weeks 

  • MRI scans 

  • Blood collection 

Your loved one is not eligible if: 

  • Have an unstable medical illness 

  • Have a diagnosis of psychotic disorder 

  • Have experienced a head injury or seizure within the past 10 yearrs 

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Click here to express interest 

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